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Luoyang QIBR Bearing Co.,LtdCall us : +86 − −(0379)63968877 // Email us : [email protected]
Luoyang QIBR Bearing Co.,LtdCall us : +86 − −(0379)63968877 // Email us : [email protected]
2017-9-25The integrated glucose‐insulin model was used to simulate and re‐estimated oral glucose tolerance tests using a crossover design of placebo and study compound Drug effects were implemented on seven different mechanisms of action (MOA) one by one or in two‐drug combinations application of a semi‐mechanistic integrated glucose
Multiple daily insulin injections have been a common regimen worldwide for the management of diabetes mellitus but involved potential safety and compliance problems In this context a single integrated microneedle patch (IMP) with multiple release kinetics is demonstrated to provide better physiologic insulin coverage for postprandial glycemic excursion in a convenient and pain-free manner
2019-9-22Grazia Aleppo and Kimberly M Webb (2018) INTEGRATED INSULIN PUMP AND CONTINUOUS GLUCOSE MONITORING TECHNOLOGY IN DIABETES CARE TODAY: A PERSPECTIVE OF REAL-LIFE EXPERIENCE WITH THE MINIMED ™ 670G HYBRID CLOSED-LOOP SYSTEM Endocrine Practice: July 2018 Vol 24 No 7 pp 684-692
In conclusion a previously presented integrated model has been extended to describe glucose and insulin concentrations in healthy volunteers following an OGTT The characterization of the differences between the healthy and diabetic stages in the IGI model could potentially be used to extrapolate drug effect from healthy volunteers to T2DM
Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models especially in large animal models remain elusive Here we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by electrostatic interaction Both high insulin loading efficiency (95%) and loading
Multiple daily insulin injections have been a common regimen worldwide for the management of diabetes mellitus but involved potential safety and compliance problems In this context a single integrated microneedle patch (IMP) with multiple release kinetics is demonstrated to provide better physiologic insulin coverage for postprandial glycemic excursion in a convenient and pain-free manner
2017-5-24optimized design of application-specific integrated circuits for the AP problem: that is a prioritized design constraint could of the controller actions and the model used for predicting future glucose variations are rendered independent That is the these subsume widely used insulin-glucose models such as linear discrete-time models
Abstract: The integrated glucose‐insulin model was originally developed on a variety of intravenous glucose provocation experiments in healthy volunteers and type 2 diabetic patients The model which simultaneously describes time‐courses of glucose and insulin based on mechanism‐based components for production elimination and homeostatic feedback has been further extended to oral
Application of a Semi-Mechanistic Integrated Glucose-Insulin Model to Graded Glucose Infusion Placebo Data Baliathan C Fancourt C Kothare P A Kjellson M C Karlsson M and Post T Application of a Semi-Mechanistic Integrated Glucose-Insulin Model to Graded Glucose Infusion Placebo Data to translate Glucose Insulin dynamics between
The integrated glucose-insulin model presented in this thesis is a semi-mechanistic model which describes glucose and insulin simultaneously The model has been used to analyze both intravenous and oral provocations and has been shown to describe and predict healthy and diabetic individuals well
2018-6-7Application of a Semi-Mechanistic Integrated Glucose-Insulin Model to Graded Glucose Infusion Placebo Data to translate Glucose Insulin dynamics between Healthy Humans and Non-Human Primates Rolien Bosch 1 * Wei Gao 2 Ryan Vargo 2 Chandni Valiathan 2 Craig Fancourt 2 P A Kothare 2 Maria C Kjellsson 3
2019-8-21The integrated multiscale mathematical model we present in this paper is built on two of our previous ones: a model of electrical oscillation in β-cells connected to neighboring cells within a three-dimensional (3D) network and a model of glucose-induced β-cell intracellular insulin granule trafficking and insulin secretion
An alternative model of glucose and insulin dynamics which also covers interindividual variability is the integrated glucose–insulin model This semi-mechanistic model is frequently used to verify drug mechanism of action quantify drug effect and trial design optimization
2005-8-25Glucose insulin minimum model delay differential equations quali-tative analysis 103 the system is an integrated physi-ological dynamic system and one should treat it as a whole and be able to conduct a single-step parameter fitting process Secondly some ofthe mathematical results clinic application We also perform
The integrated glucose-insulin model was originally developed on a variety of intravenous glucose provocation experiments in healthy volunteers and type 2 diabetic patients The model which simultaneously describes time-courses of glucose and insulin based
2019-6-15The IMM shown in Fig 1 is the integration of two sub-models the two-compartment cold glucose minimal model (Cobelli et al 1999) and insulin minimal model (Toffolo et al 2004) The insulin sub-model is a two-compartment disposition model A bolus concentration of insulin x0 (pmol/L) is released in response to the bolus glucose dose and transit compartments (Savic et al 2007) are used
2019-6-15The IMM shown in Fig 1 is the integration of two sub-models the two-compartment cold glucose minimal model (Cobelli et al 1999) and insulin minimal model (Toffolo et al 2004) The insulin sub-model is a two-compartment disposition model A bolus concentration of insulin x0 (pmol/L) is released in response to the bolus glucose dose and transit compartments (Savic et al 2007) are used
2019-10-30The treatment goal for patients with type 1 diabetes is near-normalization of plasma glucose levels Few patients achieve this even with intensive insulin treatment 1 New approaches with automatic glucose controlled insulin and glucagon delivery known as a dual-hormone artificial pancreas (AP) may offer a solution to improve glycemic control 2-6 To design and tune control algorithms for AP
Expanding on a previous analysis that established a pharmacokinetic (PK) model to describe typical profiles of insulin concentration over time following subcutaneous administration of various insulin formulations 10 the goal of the current analysis was to link the PK model for subcutaneous insulins to an integrated glucose‐insulin (IGI
Application of a Semi-Mechanistic Integrated Glucose-Insulin Model to Graded Glucose Infusion Placebo Data Baliathan C Fancourt C Kothare P A Kjellson M C Karlsson M and Post T Application of a Semi-Mechanistic Integrated Glucose-Insulin Model to Graded Glucose Infusion Placebo Data to translate Glucose Insulin dynamics between
2017-3-23glucose - insulin model J Diabetes Sci Technol 2007 1(3): 323-330 16 Basu R Della Man C Campioni M et at Effects of age and on postprandial glucose: metabolism: differences in glucose turnover insulin secretion insulin action and: hepatic insulin extraction Diabetes 2006 55(7): 2001-2014 17 Patek S D Bequette B W Breton M et al
2019-5-13We showcase this method using the Integrated Glucose Insulin (IGI) model and the Integrated Minimal Model (IMM) Additionally we try to map parameters carrying sim-ilar information between the two models Methods A bootstrap of real data and simulated datasets from both the IMM and IGI models were analyzed with the
The other important part of the combined model is the glucose control system that calculates the insulin evolution A great overview about these methods is presented in [ 23 ] Many of these algorithms are based on the original minimal model [ 24 ] which is a stable base of BGL estimation but lacks in parameter set and model complexity
An integrated model for the regulation of glucose and insulin concentrations following intravenous glucose provocations in healthy volunteers and type 2 diabetic patients was developed Data from 72 individuals were included Total glucose labeled glucose and insulin concentrations were determined
An alternative model of glucose and insulin dynamics which also covers interindividual variability is the integrated glucose–insulin model This semi-mechanistic model is frequently used to verify drug mechanism of action quantify drug effect and trial design optimization
Multiple daily insulin injections have been a common regimen worldwide for the management of diabetes mellitus but involved potential safety and compliance problems In this context a single integrated microneedle patch (IMP) with multiple release kinetics is demonstrated to provide better physiologic insulin coverage for postprandial glycemic excursion in a convenient and pain-free manner
2013-6-24The Minimal Model provides several key assessments of metabolic function including glucose tolerance (area under the glucose curve AUC g) insulin sensitivity (S I) glucose effectiveness (a measure of non-insulin mediated glucose uptake S g) acute insulin response to glucose (an in vivo assessment of pancreatic beta cell function AIR g
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